A lactosylated steroid contributes in vivo therapeutic benefits in experimental models of mouse lymphoma and human glioblastoma

…, JC Braekman, F Darro, R Kiss

Index: Delfourne, Evelyne; Darro, Francis; Portefaix, Philippe; Galaup, Chantal; Bayssade, Sylvie; Bouteille, Anne; Le Corre, Laurent; Bastide, Jean; Collignon, Francoise; Lesur, Brigitte; Frydman, Armand; Kiss, Robert Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3765 - 3771

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Citation Number: 30

Abstract

Various mono-and disaccharides were grafted onto a steroid backbone. Whereas in vitro these glycosylated steroids had no cytotoxic effects on six different human cancer cell lines, several of the glycosylated steroids under study did significantly modify the levels of in vitro migration of the human U373 glioblastoma, the A549 non-small-cell-lung cancer (NSCLC), and the PC-3 prostate cancer cells, with more pronounced effects in the case of a ...