Direct Vinylation and Difluorovinylation of Arylboronic Acids Using Vinyl-and 2, 2-Difluorovinyl Tosylates via the Suzuki− Miyaura Cross Coupling

…, AT Lindhardt, KL Jensen, T Skrydstrup

Index: Gogsig, Thomas M.; Sobjerg, Lina S.; Lindhardt, Anders T.; Jensen, Kim L.; Skrydstrup, Troels Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3404 - 3410

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Citation Number: 53

Abstract

General reaction conditions were developed for the Pd (0)-catalyzed Suzuki− Miyaura coupling reaction of aryl boronic acids with a simple electrophilic vinylation reagent, vinyl tosylate, providing access to styrene derivatives in good yields. The easily accessible vinyl tosylate represents a stable and less toxic alternative to the vinyl halides and the triflate/nonaflate derivatives. Furthermore, this methodology was expanded to provide a ...