Synthesis and biological activity of some N-substituted 2-pyrrolidones

…, RG Glushkov, LF Roshchina, AI Polezhaeva…

Index: Stezhko, T. V.; Granik, V. G.; Glushkov, R. G.; Roshchina, L. F.; Polezhaeva, A. I.; Mashkovskii, M. D. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 7 p. 478 - 482 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 7 p. 823 - 827

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Abstract

In the first stage of this investigation, the acylamidines (II-IV) were synthesized by the reaction of (I) with the diethyl acetals of dimethylformamide, dimethylacetamide, and N- methyl-2-pyrrolidone. The reactions proceeded selectively at the amide NH2 group without involving the 3-methylene group, as shown conclusively by their NIfR spectra. For example, the PMR spectrum of the amidine (III) in CDCI3 contained signals for the C--CH3, N (CH3) ...