Antimalarial 3-arylamino-6-benzylamino-1, 2, 4, 5-tetrazines

…, S Duffy, VM Avery, A Hughes, JB Baell

Index: Nhu, Duong; Duffy, Sandra; Avery, Vicky M.; Hughes, Andrew; Baell, Jonathan B. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4496 - 4498

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Citation Number: 18

Abstract

Intensive studies have focused on vaccine and drug development targeting different stages of the parasite life cycle to combat the disease. 7, 8 and 9 The search for effective vaccines, either with subunit or whole parasite approaches, is challenging due to the polymorphic nature of the parasites. 7, 8, 9 and 10 In addition, cost is also a concern as malaria is problematic in third world countries. 7 Drug treatments have been adopted and a majority of antimalarial agents in ...