Synthesis of N-benzyl-and N-phenyl-2-amino-4, 5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase

…, EC Chinje, M Jaffar, IJ Stratford, MD Threadgill

Index: Goodyer, Claire L. M.; Chinje, Edwin C.; Jaffar, Mohammed; Stratford, Ian J.; Threadgill, Michael D. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 19 p. 4189 - 4206

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Citation Number: 43

Abstract

Inhibition of the isoforms of nitric oxide synthase (NOS) has important applications in therapy of several diseases, including cancer. Using 1400W [N-(3-aminomethylbenzyl) acetamidine], thiocitrulline and Nδ-(4, 5-dihydrothiazol-2-yl) ornithine as lead compounds, series of N-benzyl-and N-phenyl-2-amino-4, 5-dihydrothiazoles and thioureas were designed as inhibitors of NOS. Ring-substituted benzyl and phenyl isothiocyanates were ...