Synthesis of 4??hydroxy??6, 9??difluorobenz [g] isoquinoline??5, 10??diones and conversions to 4??hydroxy??6, 9??bis [(aminoalkyl) amino]??benz [g] isoquinoline??5, 10?? …

AP Krapcho, MJ Maresch, CE Gallagher…

Index: Krapcho; Maresch; Gallagher; Hacker; Menta; Oliva; Di Domenico; Da Re; Spinelli Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1693 - 1702

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Citation Number: 11

Abstract

Abstract Synthetic procedures have been developed which lead to 4-hydroxy-6, 9- difluorobenz [g] isoquinoline-5, 10-dione (4a) and its 3-methyl analogue 4b. Attempts to displace the fluorides from 4a with N, N-dimethylethylenediamine were unsuccessful. Analogue 4a on treatment with N-(t-butoxycarbonyl) ethylene diamine led to 15, formed from addition of the nucleophilic amine to C-3. On the other hand, analogue 4b, on treatment ...