View all references ] The 3-position of indole is one of the building blocks for biologically active compounds. Addition of indole to nitroolefins fulfills the synthesis of 3-substituted indole. Traditionally the Michael addition of indole to nitroalkenes is catalyzed by a strong base and Brønsted acid. [ 3 3. (a) Hiemstra , H. ; Wiberg , H. Addition of aromatic thiols to conjugated cycloalkenones, catalyzed by chiral β-hydroxy amines: A mechanistic study of ...
