Several prazosin-related compounds have been synthesized and evaluated for their blocking activity toward a-adrenoreceptors. The structural modification performed on the prazosin structure included the replacement of the piperazine ring with 2, 3- dialkylpiperazine or 1, 2-~ yclohexanediamine moieties to characterize a lipophilic binding pocket in the al-adrenoreceptor surface. Cyclohexanediamine derivatives 3-6 were almost ...
