Tetrahedron

Ultrasound-assisted convenient synthesis of hypolipidemic active natural methoxylated (E)-arylalkenes and arylalkanones

BP Joshi, A Sharma, AK Sinha

Index: Joshi, Bhupendra P.; Sharma, Anuj; Sinha, Arun K. Tetrahedron, 2005 , vol. 61, # 12 p. 3075 - 3080

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Citation Number: 38

Abstract

An ultrasound-assisted convenient method was developed for the conversion of toxic methoxylated cis-isomer of arylalkenes into its hypolipidemic active trans-isomer. Treatment of cis-isomer or mixture of all three isomers () with ammonium formate and 10% Pd/C gave arylalkanes (), which upon oxidation with DDQ in anhydrous dioxane containing a little amount of silica gel, provided (E)-arylalkenes () in 42–72% yield depending upon the ...