The Journal of organic chemistry

2-Aryl-2-nitroacetates as Central Precursors to Aryl Nitromethanes, α-Ketoesters, and α-Amino Acids

AE Metz, MC Kozlowski

Index: Metz, Alison E.; Kozlowski, Marisa C. Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 717 - 722

Full Text: HTML

Citation Number: 17

Abstract

Nitroarylacetates are useful small molecular building blocks that act as precursors to α- ketoesters and aryl nitromethanes as well as α-amino acids. Methods were developed that produce each of these compound types in good yields. Two different conditions for decarboxylation are discussed for substrates with neutral and electron-poor aryl groups versus electron-rich aryl groups. For formation of the α-ketoesters, new mild conditions for ...