Synthesis and pharmacological investigation of new substituted guanidines and 2-amino-2-imidazolines

…, OV Kozlova, BA Medvedev, MD Mashkovskii

Index: Glushkov, R. G.; Nikolaeva, L. A.; Dronova, L. N.; Kozlova, O. V.; Medvedev, B. A.; Mashkovskii, M. D. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 8 p. 623 - 627 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 8 p. 951 - 955

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Abstract

Va, b, as well as a small amount of ureas Via, b could be isolated. It was shown that the ratio of la, b and Va, b in the reaction mixture greatly depends on the temperature of the process: at 0-2~ the yield of I reaches 50%, while at 30-35~ compound V is preferentially formed. The structure of the compounds obtained was confirmed by elemental analysis and mass spectral data. Compounds Vla-c were also obtained by hydrolysis of IVa-c. When IVc was ...