Tetrahedron letters

Di-μ-hydroxy-bis (N, N, N′, N′-tetramethylenediamine)-copper (II) chloride [Cu (OH)· TMEDA] 2 Cl 2: an efficient, practical catalyst for benzylation and allylation of …

G Kumaraswamy, A Pitchaiah, G Ramakrishna…

Index: Kumaraswamy; Pitchaiah; Ramakrishna; Sadaiah Tetrahedron Letters, 2006 , vol. 47, # 12 p. 2013 - 2015

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Citation Number: 13

Abstract

An efficient protocol for the benzylation or allylation of amides using the corresponding benzyl or allyl chlorides as electrophiles under basic conditions with commercially available 5mol% of [Cu (OH) TMEDA] 2Cl2 as catalyst was developed. Under these conditions, unprotected amino acids were benzylated without any racemization.