Abstract An efficient, simple and general route towards the solution-phase synthesis of four distamycin analogues containing 2− 5 N-methylcarboxamide units without the leading amide unit at the N-terminus is described. The binding abilities of these molecules to calf thymus DNA, poly d (AT), poly dA. poly dT and poly d (GC) were evaluated by duplex DNA melting temperature (T m) analysis, fluorescence probe displacement assay, footprinting ...
