Synthesis and structure–affinity relationships of 4-(5-Aryl-1, 2, 3, 6-tetrahydropyridino) pyrimidine derivatives as corticotropin-releasing factor 1 receptor antagonists

T Kumagai, T Okubo, H Kataoka-Okubo, S Chaki…

Index: Kumagai, Toshihito; Okubo, Taketoshi; Kataoka-Okubo, Hiromi; Chaki, Shigeyuki; Okuyama, Shigeru; Nakazato, Atsuro Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1349 - 1355

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Citation Number: 12

Abstract

Recently, various non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonists have been reported. Structure–affinity relationships (SARs) of non-peptide CRF1 antagonists suggest that such antagonists can be constructed of three units: a hydrophobic unit (Up-Area), a proton accepting unit (Central-Area), and an aromatic unit (Down-Area). We previously presented 4-aryl-1, 2, 3, 6-tetrahydropyridinopyrimidine derivatives ...