Tetrahedron

Highly efficient and practical phosphoramidite–copper catalysts for amination of aryl iodides and heteroaryl bromides with alkylamines and N (H)-heterocycles

Z Zhang, J Mao, D Zhu, F Wu, H Chen, B Wan

Index: Zhang, Zhanjin; Mao, Jincheng; Zhu, Di; Wu, Fan; Chen, Huilin; Wan, Boshun Tetrahedron, 2006 , vol. 62, # 18 p. 4435 - 4443

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Citation Number: 116

Abstract

A highly efficient copper-catalyzed system using phosphoramidite as ligands was applied to N-arylation of alkylamines and N (H)-heterocycles with aryl iodides and heteroaryl bromides. The reactions were carried out in relative mild conditions and good to excellent yields were obtained.