Synthesis

L-proline-catalyzed one-pot three-component reaction for the synthesis of β-alkoxy ketones

R Dodda, CG Zhao

Index: Dodda, Rajasekhar; Zhao, Cong-Gui Synthesis, 2006 , # 19 p. 3238 - 3242

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Citation Number: 12

Abstract

Abstract β-Alkoxy ketones were prepared by a one-pot three-component reaction of aliphatic aldehydes, ketones, and alcohols catalyzed by l-proline. Steric effects on the reaction were studied with substituted ketones, aldehydes, and alcohols, and the results indicate that reactions employing methyl ketones, α-unsubstituted aliphatic aldehydes and methanol produce the β-alkoxy ketones in the best yields when l-proline is used as the catalyst. The ...