Tetrahedron Letters

Synthesis of N-arylhydroxylamines by Pd-catalyzed coupling

D Beaudoin, JD Wuest

Index: Beaudoin, Daniel; Wuest, James D. Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2221 - 2223

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Citation Number: 15

Abstract

Pd-catalyzed coupling of aryl halides with TeocNHOTBS, followed by treatment of the products with TBAF, provides effective access to a wide range of N-arylhydroxylamines by a route that produces stable doubly-protected intermediates and allows the protective groups to be removed under mild conditions that do not cause extensive degradation of the final product.