Studies on syntheses and reactions of methoxypyridazines. II Methoxylation of 3, 4, 6-trichloropyridazine.

H NAGASHIMA, K UKAI, H ODA, Y MASAKI…

Index: Nagashima, Hiromu; Ukai, Kiyoshi; Oda, Hirohisa; Masaki, Yukio; Kaji, Kenji Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 350 - 356

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Citation Number: 4

Abstract

Methoxylation of 3, 4, 6-trichloropyridazine (1) with sodium methoxide was investigated in detail. Dimethoxylation of 1 afforded 6-chloro-3, 4-dimethoxypyridazine (5) and a molecular complex (M) which is composed of 5 and 3-chloro-4, 6-dimethoxypyridazine (6) in a ratio of 1: 1. The nature of the complex (M) was examined by thermal and X-ray analyses. The molecular complex (M) was also obtained by monomethoxylation of 3, 6-dichloro-4- ...