Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl …

M Ilies, MD Banciu, A Scozzafava, MA Ilies…

Index: Ilies, Monica; Banciu, Mircea D.; Scozzafava, Andrea; Ilies, Marc A.; Caproiu, Miron T.; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 10 p. 2227 - 2239

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Citation Number: 21

Abstract

Novel matrix metalloproteinase (MMP)/bacterial collagenase inhibitors are reported, considering the sulfonylated amino acid hydroxamates as lead molecules. A series of compounds was prepared by reaction of arylsulfonyl isocyanates with N-(5H-dibenzo [a, d] cyclohepten-5-yl)-and N-(10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) methyl glycocolate, respectively, followed by the conversion of the COOMe to the carboxylate/ ...