Reversible aminal formation: Controlling the evaporation of bioactive volatiles by dynamic combinatorial/covalent chemistry

…, A Trachsel, JY de Saint Laumer…

Index: Buchsnee Levrand, Barbara; Godin, Guillaume; Trachsel, Alain; De Saint Laumer, Jean-Yves; Lehn, Jean-Marie; Herrmann, Andreas European Journal of Organic Chemistry, 2011 , # 4 p. 681 - 695

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Citation Number: 15

Abstract

Abstract Dynamic mixtures generated by reversible aminal formation efficiently prolong the duration of evaporation of bioactive volatile aldehydes. Secondary diamines used for the generation of dynamic mixtures are obtained by treatment of primary diamines with carbonyl compounds and reduction of the diimines with NaBH 4. The reversibilities of the reactions were demonstrated by NMR measurements in buffered aqueous solutions. Kinetic rate ...