Scheme I"(a) 1.0 equiv of n-BuLi, ether, 0 OC, 0.5 h; COz, 88-94%;(b) 0.6 equiv of EDCbHCl, CHZClz, 25" C, 15 min, 86%;(c) Table I. petitive N-1 vs. C-3 acylation of indole has required the empirical determination of experimental conditions which favor predominant or exclusive N-acylati~ n.~~~ In addition, for systems for which no activated acylation reagent is available, the indole N-carbonyl compounds are currently inaccessible.
