Discovery of 5??(2??(Phenylamino) pyrimidin??4??yl) thiazol??2 (3H)??one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation

S Diab, T Teo, M Kumarasiri, P Li, M Yu, F Lam…

Index: ChemMedChem, , vol. 9, # 5 p. 962 - 972

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Citation Number: 20

Abstract

... ChemMedChem, 9: 962–972. ... Volume: Issue: Page ... o as a white powder (7.81 g, 95 %): 1 H NMR ([D 6 ]DMSO): δ=3.10 (s, 3 H, CH 3 ), 7.58–7.67 (m, 2 H, Ph-H), 7.92–7.96 (m, 1 H, Ph-H), 8.04 (s, 1 H, Ph-H), 10.37 ppm (s, 1 H, NH); HRMS (ESI): m/z [M+H] + calcd for C 7 H 9 N 2 ...