The synthesis of novel 3′, 5′-homocyclic nucleotides as potential anti-HIV agents

MGB Drew, JHM Gould

Index: Drew, Michael G. B.; Gorsuch, Stephen; Gould, Jayne H. M.; Mann, John Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 8 p. 969 - 978

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Citation Number: 5

Abstract

(5S)-(5-tert-Butyldimethylsiloxymethyl) furan-2 (5H)-one has been converted into cytosine 2′, 3′-dideoxy-3′, 5′-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.