Design, synthesis, and evaluation of novel biarylpyrimidines: A new class of ligand for unusual nucleic acid structures

RT Wheelhouse, SA Jennings, VA Phillips…

Index: Wheelhouse, Richard T.; Jennings, Sharon A.; Phillips, Victoria A.; Pletsas, Dimitrios; Murphy, Peter M.; Garbett, Nichola C.; Chaires, Jonathan B.; Jenkins, Terence C. Journal of Medicinal Chemistry, 2006 , vol. 49, # 17 p. 5187 - 5198

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Citation Number: 35

Abstract

Biarylpyrimidines are characterized as selective ligands for higher-order nucleic acid structures. A concise and efficient synthesis has been devised incorporating Suzuki biaryl cross-coupling of dihalopyrimidines. Two ligand series are described based on the parent ...