Background Isoxazoles are most frequently prepared by reaction of 1, 3-diketones with hydroxylamine (eq lh5 The procedure works well for symmetrical 1, 3-diketones and can be extended to unsymmetrical 1, 3-diketones that have alkyl groups of moderately different steric bulk attached to the carbonyl carbons. If the two alkyl groups are of similar steric bulk, a mixture of regioisomers is~ btained.~,~ More recently, Olofson7* has addressed this ...
![2-[bis(methylsulfanyl)methylidene]cyclohexan-1-one Structure](https://image.chemsrc.com/caspic/134/17649-90-0.png)
![N-[2-[bis(methylsulfanyl)methylidene]cyclohexylidene]hydroxylamine Structure](https://image.chemsrc.com/caspic/278/118631-08-6.png)