Tetrahedron Letters

Synthesis of oxazoles through Pd-catalyzed cycloisomerization–allylation of N-propargylamides with allyl carbonates

A Saito, K Iimura, Y Hanzawa

Index: Saito, Akio; Iimura, Koichi; Hanzawa, Yuji Tetrahedron Letters, 2010 , vol. 51, # 11 p. 1471 - 1474

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Citation Number: 36

Abstract

In the presence of Pd2 (dba) 3-Cy3P catalyst, IPr· HCl salt [IPr= 1, 3-bis (2, 6- diisopropylphenyl) imidazol-2-ylidene], and Cs2CO3, N-propargylamides react with allyl carbonates to give 2, 5-disubstituted oxazoles having homoallyl groups through the tandem cycloisomerization–allylation.