Structure-based, C2 symmetric inhibitors of HIV protease

…, WE Kohlbrenner, NE Wideburg, DA Paul…

Index: Kempf; Norbeck; Codacovi; Wang; Kohlbrenner; Wideburg; Paul; Knigge; Vasavanonda; Craig-Kennard; et al. Journal of medicinal chemistry, 1990 , vol. 33, # 10 p. 2687 - 2689

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Citation Number: 207

Abstract

New Zealand rabbits (2.2-2.3 kg) were fed a cholesterol-rich die P for 10 days to induce increases in arterial ACAT activity'” and then switched to Purina chow lb (calculated to provide 50 mg kg-'day-'). After 6 days, the aortas were excised, incubated in vitro with [l-14C] oleate for 3 h, and ACAT activity was evaluated by the formation of cholesteryl [“CJ-oleate. 16 Liver minces” from male Sprague-Dawley rats (435-460 g) that received a Purina chow ...