Crystal Structures of Two Vancomycin Complexes with Phosphate and N-Acetyl-D-Ala. Structural Comparison between Low-Affinity and High-Affinity Ligand …

T Kikuchi, S Karki, I Fujisawa, Y Matsushima…

Index: Kikuchi, Takanori; Karki, Shyam; Fujisawa, Ikuhide; Matsushima, Yoshitaka; Nitanai, Yasushi; Aoki, Katsuyuki Bulletin of the Chemical Society of Japan, 2010 , vol. 83, # 4 p. 391 - 400

Full Text: HTML

Citation Number: 2

Abstract

Crystal structures of two vancomycin complexes with phosphate and N-acetyl–D-Ala (AcDA) were determined. Each complex involves two crystallographically independent vancomycin molecules (V1 and V2) in the asymmetric unit, which form a usually observed back-to-back arranged vancomycin dimer V1–V2 with two disaccharide chains packed in a head-to-head manner, but only one of the two ligand-binding sites is occupied. Comparison of the ...