Low-generation dendrimers with a calixarene core and based on a chiral C2-symmetric pyrrolidine as iminosugar mimics

M Marradi, S Cicchi, F Sansone…

Index: Marradi, Marco; Cicchi, Stefano; Sansone, Francesco; Casnati, Alessandro; Goti, Andrea Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 951 - 957

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Citation Number: 14

Abstract

Abstract The preparation of low-generation dendrimers based on a simple calix [4] arene scaffold by insertion of the iminosugar-analogue C 2-symmetric 3, 4-dihydroxypyrrolidine is described. This methodology allows a rapid incorporation of a considerable number of iminosugar-like moieties in a reduced volume and in a well-defined geometry. The inclusion of alkali-metal ions (sodium and potassium) in the polar cavity defined by the acetamide ...