Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks

…, LM Jones, GE Chavarria, AK Charlton-Sevcik…

Index: Song, Jiangli; Jones, Lindsay M.; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Jantz, Adam; Johansen, Audra; Bayeh, Liela; Soeung, Victoria; Snyder, Lindsey K.; Lade Jr., Shawn D.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2801 - 2807

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Citation Number: 8

Abstract

Cathepsin L is a cysteine protease that is upregulated in a variety of malignant tumors and plays a significant role in cancer cell invasion and migration. It is an attractive target for the development of small-molecule inhibitors, which may prove beneficial as treatment agents to limit or arrest cancer metastasis. We have previously identified a structurally diverse series of thiosemicarbazone-based inhibitors that incorporate the benzophenone and ...