Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging

…, W Kraus, HJ Pietzsch, J Kropp…

Index: Jung, Christian M.; Kraus, Werner; Leibnitz, Peter; Pietzsch, Hans-Juergen; Kropp, Joachim; Spies, Hartmut European Journal of Inorganic Chemistry, 2002 , # 5 p. 1219 - 1225

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Citation Number: 30

Abstract

Technetium-labeled fatty acids intended for myocardial metabolism imaging and the respective rhenium model complexes were synthesized according to the “4+ 1” mixed-ligand approach and investigated in vitro and in vivo. The non-radioactive rhenium model complexes were characterized by NMR, IR, and EA, and the geometrical impact of the chelate unit on the integrity of the fatty acid head structure was determined by single- ...