Two-step N-acylindazole to N-alkylindazole reduction. Further synthetic studies on the serotonergic agonist AL-34662

…, P Delgado, WD Dean, GR Callen, SV Plummer

Index: Conrow, Raymond E.; Delgado, Pete; Dean, W. Dennis; Callen, Gary R.; Plummer, Scott V. Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2348 - 2350

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Citation Number: 3

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A synthesis of the title compound, operable on kilogram scale, employs reductive acetylation of an N-acylindazole to give a hemiaminal acetate followed by deacetoxylation to the corresponding N-alkylindazole. ... The two-step method avoids C–N bond cleavage, which ...