Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity

…, E Petricci, S Massa, F Corelli, M Botta

Index: Petricci, Elena; Mugnaini, Claudia; Radi, Marco; Corelli, Federico; Botta, Maurizio Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 7880 - 7887

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Citation Number: 55

Abstract

A simple and efficient methodology for the parallel solution-phase synthesis has been set up to obtain a series of thiouracils, in turn selectively S-benzylated under microwave irradiation to give new S-DABOs. Biological screening led to the identification of compounds with nanomolar activity toward both the highly purified recombinant human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) enzyme (wild-type and mutants) and wild- ...