5-Fluorouracil derivatives. X. Synthesis and antitumor activities of. ALPHA.-alkoxyalkyl-5-fluorouracils.

…， 古川弘幸， 上村敦彦， 石川勝敏, K ISHIKAWA…

Index: Ozaki; Watanabe; Hoshiko; Nagase; Ogasawara; Furukawa; Uemura; Ishikawa; Mori Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 150 - 157

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Citation Number: 23

Abstract

With the aim of diminishing the toxicity of 5-fluorouracil (1) and obtaining biologically active derivatives of 1 suitable for oral administration, α-alkoxyalkyl groups were introduced at the 1-, 3-and 1, 3-positions of 1. Alkoxyalkylation can be effected by four methods:(i) reaction of