The Journal of Organic Chemistry

Zinc-mediated conversion of β-keto esters to γ-keto esters

JB Brogan, CK Zercher

Index: Brogan, John B.; Zercher, Charles K. Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6444 - 6446

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Citation Number: 57

Abstract

The efficient preparation of γ-keto esters has been the goal of numerous research efforts. Although methods have been developed in which the ketone and ester functionalities are brought together from different sources, 1 reactions which promote the insertion of a single methylene unit between the carbonyl functionalities of a readily accessible β-keto ester have dominated these efforts. The formation and fragmentation of 2-carboxycyclopropyl ...