Synthesis of new alkylaminoalkyl thiosemicarbazones of 3-acetylindole and their effect on DNA synthesis and cell proliferation

T Siatra-Papastaikoudi, A Tsotinis…

Index: Siatra-Papastaikoudi; Tsotinis; Raptopoulou; Sambani; Thomou European Journal of Medicinal Chemistry, 1995 , vol. 30, # 2 p. 107 - 114

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Citation Number: 22

Abstract

The preparation of a number of thiosemicarbazones of 3-acetylindole is described. These compounds were evaluated in vitro for their effect on proliferation and cell-division delays in cultured human peripheral blood lymphocytes, and their effect on DNA synthesis in T-cell leukemia Molt-4 cells.