Tetrahedron letters

Synthesis of substituted 4-(3-alkyl-1, 2, 4-oxadiazol-5-ylmethyl)-3, 4-dihydro-2H-1, 4-benzoxazines and 4-(1H-benzimidazol-2-ylmethyl)-3, 4-dihydro-2H-1, 4- …

P Mizar, B Myrboh

Index: Mizar, Pushpak; Myrboh, Bekington Tetrahedron Letters, 2006 , vol. 47, # 44 p. 7823 - 7826

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Citation Number: 15

Abstract

Substituted 2H-1, 4-benzoxazines were synthesized from substituted 2-amino phenols and 1, 2-dibromoethane using K2CO3 in good to excellent yields. The cyclized products were further reacted with alkyl bromides to obtain the desired N-substituted 3, 4-dihydro-2H-1, 4- benzoxazines.