Synthesis and pharmacokinetic profile of a quaternary ammonium derivative of chlorambucil, a potential anticancer drug for the chemotherapy of chondrosarcoma

M Rapp, I Giraud, JC Maurizis, JC Madelmont

Index: Rapp, Maryse; Giraud, Isabelle; Maurizis, Jean-Claude; Madelmont, Jean-Claude Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5007 - 5012

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Citation Number: 11

Abstract

As a part of our targeting program based on the affinity of the quaternary ammonium moiety for cartilage, our objective was to develop more selective anticancer drugs towards chondrosarcoma that would concentrate in this malignant cartilaginous tissue and so improve the therapeutic index through a reduction of side effects. For this purpose we have synthesized and labeled with 14C a quaternary ammonium (QA) derivative of ...