6-Hydroxy-4-[2-di-n-propylaminoethyl] indole: synthesis and dopaminergic actions

JG Cannon, T Lee, M Ilhan, J Koons…

Index: Cannon; Lee; Ilhan; Koons; Long Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 386 - 389

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Citation Number: 22

Abstract

Chemistry. As shown in Scheme I, application of the Batcho-Leimgruber modifications of the Reissert indole synthesis (9-10-11) requires an o-nitrotoluene derivative, 10, bearing an oxygen function at position 4 and a functionality (in this case, carbomethoxy) at position 6, capable of being homologated to an aminoethyl moiety. Terpko and Heckg found that a triethylammonium for-