Method for the preparation of 1, 3-bis (p-chlorobenzylideneamino) guanidine

VI Zaionts, NA Zakharova, LA Korovitskaya…

Index: Zaionts, V. I.; Zakharova, N. A.; Korovitskaya, L. A.; Agrest, F. B.; Krylov, M. V.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 637 - 638 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 972 - 973

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Abstract

The step involving the II § transformation has substantial technological disadvantages boiling of the hydrochloric acid solution, which gives rise to corrosion of the apparatus, the prolonged expenditure of energy in the removal of III by steam distillation, which leads to large volumes of acidic waste water, and the pollution of the plant atmosphere with III, which irritates the mucous membranes [18].