e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Journal of heterocyclic chemistry
Synthesis of heterocyclic compounds using amidines as their ene??1, 1??diamine tautomers. II. Synthesis of 2, 3??dihydropyridine, 3, 4??dihydropyridine and 3, 4?? …
Nt-Butylacetamidines 1 on heating with methyl vinyl ketone, acrolein or crotonaldehyde gave the 2, 3-dihydropyridine derivatives 4, 5 or 6 via N-alkylation of the acetamidines 1. Reaction of amidines 1 with phenyl 1-propenyl ketone, benzalacetone or chalcone gave 3, 4- dihydropyridine derivatives 8, 9 or 10. These were obtained by C-alkylation, achieved by Michael addition of the acetamidines 1 as their N, C-tautomers ene-1, 1-diamines 1'to α, β- ...
