Tetrahedron

A novel synthesis of hexahydroazoninoindoles using activated alkynes in an azepine ring expansion

LG Voskressensky, SV Akbulatov, TN Borisova…

Index: Voskressensky, Leonid G.; Akbulatov, Sergey V.; Borisova, Tatiana N.; Varlamov, Alexey V. Tetrahedron, 2006 , vol. 62, # 52 p. 12392 - 12397

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Citation Number: 31

Abstract

Monocyclic and annulated medium-ring N-containing heterocycles are an important class of compounds, occurring in a wide range of natural and synthetic products. 1, 1a, 1b and 1c There is a sound basis for their appeal in pharmacological research; they are of moderate size giving rise to their potential as ligands for receptors, and they offer semi-restricted conformational flexibility allowing considerable scope for selective binding with a range of functional groups. 2, 2a ...