Synthetic Communications

Polyethylene Glycol–Enhanced Chemoselective Synthesis of Organic Carbamates from Amines, CO2, and Alkyl Halides

DL Kong, LN He, JQ Wang

Index: Kong, De-Lin; He, Liang-Nian; Wang, Jin-Quan Synthetic Communications, 2011 , vol. 41, # 22 p. 3298 - 3307

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Citation Number: 8

Abstract

Abstract An efficient and environmentally benign method for the synthesis of organic carbamates was developed. Amines, CO2, and alkyl halides underwent a three-component reaction with the aid of K2CO3 and polyethylene glycol (PEG, MW= 400), affording the organic carbamates under ambient conditions. PEG could presumably act as a solvent and phase-transfer catalyst (PTC). Notably, the presence of PEG could also depress the ...