Tetrahedron

Regioselective arylation of uracil and 4-pyridone derivatives via copper (I) bromide mediated C–H bond activation

C Cheng, YC Shih, HT Chen, TC Chien

Index: Cheng, Chien; Shih, Yu-Chiao; Chen, Hui-Ting; Chien, Tun-Cheng Tetrahedron, 2013 , vol. 69, # 4 p. 1387 - 1396

Full Text: HTML

Citation Number: 13

Abstract

A facile and effective synthesis of 6-aryluracil derivatives was accomplished by the direct C– H bond activation for arylation. A series of 6-aryl-1, 3-dimethyluracils were synthesized from the reaction of 1, 3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper (I) bromide as the catalyst and lithium tert-butoxide as the base. This methodology is applicable to a variety of 5-substituted uracils as well as 4-pyridone to provide direct ...