Palladium-catalyzed synthesis of 2-quinolone derivatives from 2-iodoanilines

NA Cortese, CB Ziegler Jr, BJ Hrnjez…

Index: Cortese,N.A. et al. Journal of Organic Chemistry, 1978 , vol. 43, p. 2952 - 2958

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Citation Number: 131

Abstract

1, 2-Disubstituted olefins undergo the vinylic substituilon reaction with triarylphosphine- palladium acetate catalysts, stereospecifically via a syn addition of the organopalladium intermediate followed by a syn “palladium hydride” elimination. 2 In the absence of a triarylphosphine, aryl iodides, but not bromides, reacted also, but with considerable loss of atereochemistry, presumably because of multiple palladi um hydride readdition- ...