Synlett

The use of diethylaminosulfur trifluoride (DAST) for fluorination in a continuous-flow microreactor

M Baumann, IR Baxendale, SV Ley

Index: Baumann, Marcus; Baxendale, Ian R.; Ley, Steven V. Synlett, 2008 , # 14 p. 2111 - 2114

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Citation Number: 45

Abstract

To perform the fluorination reactions in a convenient and safe way we decided to use the R2+/R4 combination flow reactor commercially available from Vapourtec. [¹¹] Exploiting the injection loop system of the R2+ unit was found to be very valuable since any contact of the metal parts of the pumping system with the corrosive DAST reagent was thereby avoided. In addition due to the nature of the tubular reactor material (PEEK, PTFE, PFA) no ...