Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists

…, M Crockatt, L Evans, H Feilden, RR Goodwin…

Index: Palin, Ronald; Barn, David R.; Clark, John K.; Cottney, Jean E.; Cowley, Phillip M.; Crockatt, Marc; Evans, Louise; Feilden, Helen; Goodwin, Richard R.; Griekspoor, Frank; Grove, Simon J.A.; Houghton, Andrea K.; Jones, Philip S.; Morphy, Richard J.; Smith, Alasdair R.C.; Sundaram, Hardy; Vrolijk, David; Weston, Mark A.; Wishart, Grant; Wren, Paul Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 589 - 593

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Citation Number: 12

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure–activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified. ... A series of potent and soluble ...