Termination of radical-polar crossover reactions by intramolecular nucleophiles

JA Murphy, F Rasheed, SJ Roome…

Index: Murphy, John A.; Rasheed, Faiza; Roome, Stephen J.; Lewis, Norman Chemical Communications, 1996 , # 6 p. 737 - 738

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Abstract

Scheme 4 Reagents and conditions: i,(Et0) 3P, neat, reflux, 4 h, 71%; ii, NaH, MeCOMe, 0" C to room temp., 37 h, 58%; iii, LiAl&, Et20, reflux, 1 h, 94%; iv, TBDPSCI, imidazole, DMF, 16 h, 69%; v, N02C&0H, Ph3P, DEAD, THF, 0" C to room temp., 14 h, 71%; vi, TBAF, THF, 4 h, 99%; vii, NaBa, Cu (acach, EtOH, 71%; viii, NOBF4, CH2C12, OOC, 5 min. followed by'ITF, moist acetone, room temp., 30 min, 57% above, we found that diazotisation of mine 12 ...