Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues

…, JM Nam, CS Lee, EM Ha, ES Lee, Y Kwon…

Index: Woo, Sangwook; Kang, Da-Hye; Nam, Jung Min; Lee, Chong Soon; Ha, Eun-Mi; Lee, Eung-Seok; Kwon, Youngjoo; Na, Younghwa European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 4221 - 4228

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Citation Number: 14

Abstract

In order to develop potential anti-cancer agents that act on topoisomerase II and DNA, we have synthesized 12 new xanthone derivatives. In the cytotoxicity test, compounds 17 and 31 exhibited 2-to 7-fold stronger inhibitory activity than adriamycin against most cancer cell lines tested. Halohydrin group-tethered compounds 19, 21 and 27 showed comparable topoisomerase II inhibitory activity to etoposide at 100μM concentration. In the DNA cross- ...