Synthesis and biological properties of hydroxythioether fatty acids related to leukotrienes: antagonists and agonists of slow-reacting substance of anaphylaxis (SRS-A)

W Ho, WE Hageman, KG Stanley, WR Gallant…

Index: Ho, W; Hageman, W E; Stanley, K G; Gallant, W R; Cherry, D A; et al. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 3 - 12

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Abstract

Abstract A series of 6-hydroxy-7-thioether and 6-thioether-7-hydroxy derivatives of commercially available petroselinic acid and 5-hydroxy-6-thioether derivatives of fatty acids containing an aromatic moiety were synthesized. Several of the compounds have exhibited SRS-A antagonist (eg, 5, 10)/agonist (eg, 34, 35) activity. Compound 5 antagonized SRS-A- induced contractions of the isolated guinea pig ileum with IC 50= 0.09 μM.